Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity
نویسندگان
چکیده
منابع مشابه
Antidepressant drugs affect dopamine uptake
The catecholamine hypothesis of depression postulates a deficiency of norepinephrine at functional receptor sites. The evidential basis derives from studies on the turnover and uptake of norepinephrine and the blockade of reuptake by tricyclic antidepressants El 3]. Serotonin systems may also be involved in antidepressant drug action [4, 5]. Relatively little attention has been paid to the poss...
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چکیده ندارد.
Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase.
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[3H]Mazindol labels neuronal dopamine uptake sites in corpus striatum membranes (KD = 18 nM) and neuronal norepinephrine uptake sites in cerebral cortex and submaxillary/sublingual gland membranes (KD = 4 nM). The potencies of various inhibitors of biogenic amine uptake in reducing [3H]mazindol binding in striatal membranes correlate with their potencies for inhibition of neuronal [3H]dopamine ...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2012
ISSN: 1948-5875,1948-5875
DOI: 10.1021/ml300262e